Microsoft's Arc, the 3D-Spheric-Mouse, the AirMouse and the Orbita. The latest product to take a shot at the title is the ErgoSlider Plus+, a device that looks like a padded wrist rest, but with a cylinder at the front that rolls and slides in a special groove to move the onscreen cursor.
Ektouch, the makers of the ErgoSlider Plus+, say the device is clinically proven to reduce muscle strain by letting users move the onscreen pointer without overusing their wrists. With your wrists resting on the visco-elastic padding at the bottom, rolling the cylinder up and down moves the pointer along the Y-axis, while sliding the cylinder left and right moves it along the X-axis. There are five buttons located centrally between the padding and the roller with the middle one acting as a scroll wheel.
Source: gizmag